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Sign In Sign In to gain access to subscriptions and/or My Tools. ACCP Members, please sign in at ACCP to access the journal online. Rosuvastatin: A Review of its Use in the Prevention of Cardi... : American Journal of Cardiovascular Drugs Adis may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy.) is an HMG-CoA reductase inhibitor (statin) that has both lipid-lowering and anti-inflammatory effects. The drug has various indications in the US, including the primary prevention of cardiovascular disease (CVD) in patients with no clinical evidence of coronary heart disease who are at increased risk of CVD based on their age, a high-sensitivity C-reactive protein (hsCRP) level of ?2?mg/L, and at least one other CVD risk factor.The efficacy of rosuvastatin in apparently healthy women (aged ?60 years) or men (aged ?50 years) with normal low-density lipoprotein cholesterol (LDL-C) levels and elevated hsCRP levels was demonstrated in the large, randomized, double-blind, multinational, JUPITER trial. Relative to placebo, rosuvastatin 20?mg once daily for a median follow-up of 1.9 years significantly reduced the occurrence of first major cardiovascular events in this trial (primary endpoint). A between-group difference in favor of rosuvastatin was also demonstrated for various other endpoints, including overall deaths and the nonatherothrombotic endpoint of venous thromboembolism. Rosuvastatin remained more effective than placebo when primary endpoint results were stratified according to various baseline factors, including in patient subgroups thought to be at low risk of CVD. Rosuvastatin Reviews Ratings at Drugs.com A B C D E F G H I J K L M N O P Q R S T U V W X Y Z Advanced Phonetic Started on Crestor 5 mg a year and a half ago. It immediately lowered my Cholesterol by 60 points. No problems until 4 months ago. Started having heart palpitations, mainly at night which is when I took the Crestor. They got so severe, I would be up all night. After doing a lot of researching on the internet, I found that other people had experienced this too, so I stopped the medicine and haven't had any palpitations since. My doc seems reluctant to believe this was the cause.A review on the rationale and clinical use of concomitant rosuvastatinA review on the rationale and clinical use of concomitant rosuvastatin and fenofibrate/fenofibric acid therapy Mixed dyslipidemia, characterized by a lipid triad of elevated triglycerides (TG), elevated low-density lipoprotein-cholesterol (LDL-C) and reduced high-density lipoproteincholesterol (HDL-C), is a common and frequently difficult to manage condition. The use of combination medications is often needed to effectively treat the lipid triad. The co-administration of statins and fibrates may provide the desired endpoints but safety issues such as toxicity to the muscles, liver and kidneys are a concern. Given the potency of rosuvastatin to lower LDL-C and fenofibrate s effectiveness in lowering TG, the use of this specific combination may be desirable in treating mixed dyslipidemia. Pharmacokinetic studies revealed no significant interactions with the concomitant use of rosuvastatin and fenofibrate or its active metabolite fenofibric acid.
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